PING MR Acquisition Core
PING is applying a standardized high-resolution structural MRI protocol involving 3-D T1-weighted scans, a T2-weighted volume, a set of diffusion-weighted scans with multiple b values and diffusion directions, and gradient echo EPI scans for resting state fMRI. Importantly, adaptive motion compensation, using "PROMO", a novel real-time motion correction algorithm will be used. This method dramatically improves the image quality obtained when subjects are unable to remain entirely still in the scanner. Specific PING protocols for each scanner manufacturer are provided below.
PING MR Post-Processing Core
Post-processing will be performed with Freesurfer, the TBSS tools in FSL, and an atlas-based method for labeling and characterizing fiber tracts developed in the MultiModal Imaging Laboratory at the University of California, San Diego.
Figures 1 and 2. Diffusion parameters from major brain fiber tracts.
Figure 3. Cortical surface areas and cortical thicknesses for parcels as shown (from FreeSurfer).